10 Impartial Caffeine Research Studies

10 Impartial Caffeine Research Studies For Fact-Based Decision Making


Below are links to some of the major research that drove our decision-making. These are independent studies that provide insights into caffeine and caffeine withdrawal. Here, you see the science supporting general vitamin effectiveness that guided our fact-based decision making. 

A scientific paper published in 2018 gave the most recent validation that drinking coffee is not the best way to absorb caffeine.[1] But there are actually many more going back 20 years that have largely gone unnoticed.[2]

What we did with CAFFEINEcontrol was build on this caffeine research and combine their findings in a groundbreaking new effort to not just deliver caffeine faster, but to instead microdose it in combination with other active ingredients to deliver a low-caffeine alternative that lets you reduce or elminate caffeine without ever triggering caffeine withdrawal.



Zinc effectively reduced the duration of a cold, in many studies.

Further, it supports immune system health as well as effective dopamine (“feel-good” hormone) production. 



Caffine research confirms caffeine does not appear to help you as much as you think it does. What you consider “making you feel good”, may actually just be that interuping dependence symptoms and stopping you from feeling bad.

L-Theanine and Caffeine Research


L-Theanine replicates the calming effects found in a cup of tea.

Caffeine research here confirms that L-Theanine helps counteract the sleep disturbances that often accompany caffeine use. But most importantly, caffeine research has confirmed that L-Theanine, when combined with caffeine, is more effective than alone.

Caffeine Research on Overconsumption


The FDA has outlined how much is too much caffeine. With this in mind, their caffeine research outlines the factors that can lead to addiction and even death.

Similar to the FDA report, the Netherlands Nutrition Centre has also outlined guidelines that serve as the guard rails for safe and sane consumption in Europe.

Vitamin C Research


While not specifically related to caffeine, this research details the link to both immune health and mood related to Vitamin C.

A Historical Perspective


Research by University of Rome. They detail the historical and current impacts of caffeine use. The study also details incidents of accidental overdose.

This study was especially interesting in that it provides a historical perspective that modern society did not invent caffeine addiction to try to get more done.

FDA Facts


US Food and Drug Administration article on how much caffeine is too much.


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Additional Caffeine Research:

[1] . Wickham, K.A., Spriet, L.L. Administration of Caffeine in Alternate Forms. Sports Med 48, 79–91 (2018). https://doi.org/10.1007/s40279-017-0848-2

[2] . Kamimori GH, Penetar DM, Headley DB, et al. Effect of three caffeine doses on plasma catecholamines and alertness during prolonged wakefulness. Eur J Clin Pharmacol. 2000;56:537–44.